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APC - anti mouse CD25 - Clone PC61
品牌：Immunostep
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APC - anti mouse CD25 - Clone PC61
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APC - anti Mouse CD25 - PC61

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89,00 € tax excl.

206,00 € tax excl.

Product Description

  • PC61
  • Rat IgG1
  • Flow Cytometry
  • APC
  • 0.2 mg/ml
  • IL-2-dependent cytolytic mouse T-cell clone B6.1
  • Mouse
  • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
  • RUO
  • Liquid
  • Store in the dark at 2-8 °C
Mouse APC Vial View larger
CD25, the low-affinity IL-2 Receptor α chain (IL-2Rα, p55) expressed on activated T and B lymph ocytes from all mouse strains tested. IL-2Rα by itself is not a signaling receptor. However, it can combine with IL-2 Receptor β (CD122) and γc (CD132) chains to form high-affinity, signaling receptor complexes for IL-2. Resting T and B lymph ocytes and resting and activated NK cells do not express IL-2Rα. CD25 is transiently expressed at a low level during normal B-cell development in the bone marrow on the CD45R/B220low TdT- sIg- Pre-B/Pre-B-II and CD45R/B220low TdT- sIgM+ sIgD- immature B stages, but not on the CD45R/B220low TdT+ sIg- Pro-B/Pre-B-I stage nor on CD45R/B220high TdT- sIgM+ sIgD+ mature B cells. It is expressed at a higher level during a very early stage of T-cell development in fetal and ***** thymus. Peripheral CD25+CD4+ lymph ocytes called regulatory T (Treg) cells are involved in the maintenance of self-tolerance. It has also been reported that dendritic cells express CD25, recognized by mAb 7D4. The PC61 antibody recognizes an epitope of CD25 which is distinct from the IL-2 and from those recognized by mAbs 3C7 and 7D4. It blocks binding of IL-2 to CD25, presumably by inducing a conformational change in CD25.
  • Interleukin-2 receptor alpha chain; IL-2RA; IL-2R?; Il2ra; IL-2R p64
  • 16184
  • 55 kD
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