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CD45RA/CD4 - IMMUNOSTEP. WE KNOW HOW

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CD45RA/CD4 - IMMUNOSTEP. WE KNOW HOW

商品详情参考文献相关资料

FITC/ PE - anti Human CD45RA/CD4 - HI100, HP2/6

Reference	Size	Price	Quantity	Add to cart
45RAF24PE1-50T	50 test	242,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

45RAF24PE1-50T

50 test

242,00 € tax excl.

Product Description

Clone: HI100, HP2/6
Isotype: IgG1, IgG2a
Tested Applications: FCM
Conjugated: FITC/ PE
Species Reactivity: Human
Storage Buffer: PBS, 0,09% sodium Azide, may contain carrier protein-stabilizer
Regulatory Status: RUO

Antigen details

Large description:

CD45RA /CD4 is intended for use in flow cytometry. Measurement of the relative as well as the absolute number of CD4- positive cells in peripheral blood is critically important in assessing the immunological status of a patient. The CD4 antigen is is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD45 Leukocyte Common Antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. CD45RA is expressed on approximately 75% of CD8 lymphocytes and 50% of CD4 lymphocytes, all B cells and NK Cells. CD45RA antigen is expressed on naive T lymphocytes, antigen density decreases upon in vitro activation. A decrease antigen density has been demonstrated for CD4+CD45RA+subset with active multiple sclerosis.

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