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Anti-FANCC Antibody

品牌：Antibodies

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规格：100µl

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Anti-FANCC Antibody

商品详情参考文献相关资料

Name:	Anti-FANCC Antibody See all FANCC primary antibodies
Description:	Rabbit polyclonal antibody to FANCC
Specificity:	The antibody detects endogenous level of total FANCC protein.
Applications:	WB, IHC, IF
Reactivity:	Human
Immunogen:	Recombinant protein of human FANCC.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were purified by affinity purification using immunogen.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Function:	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Tissue Specificity:	Ubiquitous.
Involvement in Disease:	Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Cellular locations:	Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Database Links:	Entrez Gene: 2176?Human Omim: 613899?Human SwissProt: Q00597?Human Unigene: 494529?Human
Synonyms:	bA80I15.1 Antibody FA 3 Antibody FA3 Antibody FAC Antibody FACC Antibody FANCC Antibody FANCC_HUMAN Antibody Fanconi anemia complementation group C Antibody Fanconi anemia complementation group C protein Antibody Fanconi anemia group C protein Antibody Fanconi pancytopenia type 3 Antibody FLJ14675 Antibody Protein FACC Antibody
Information:	Target information shown above is from the UniProt Consortium.