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Anti-EZH1 Antibody

品牌：Antibodies

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规格：50µl

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Anti-EZH1 Antibody

商品详情参考文献相关资料

Name:	Anti-EZH1 Antibody See all EZH1 primary antibodies
Description:	Rabbit polyclonal antibody to EZH1.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EZH1.
Protein Length:	747
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Sequence Similarities:	Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
Cellular locations:	Nucleus. Colocalizes with trimethylated 'Lys-27' of histone H3.
Database Links:	Entrez Gene: 2145?Human Entrez Gene: 14055?Mouse Entrez Gene: 303547?Rat Omim: 601674?Human SwissProt: Q92800?Human SwissProt: P70351?Mouse Unigene: 194669?Human Unigene: 5027?Mouse Unigene: 154549?Rat
Synonyms:	Enhancer of zeste homolog 1 Antibody Enhancer of zeste homolog 1 (Drosophila) Antibody ENX-2 Antibody ENX2 Antibody EZH1 Antibody EZH1_HUMAN Antibody Histone-lysine N-methyltransferase EZH1 Antibody
Information:	Target information shown above is from the UniProt Consortium.