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Anti-eIF2Bdelta Antibody

品牌：Antibodies

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规格：100µl

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Anti-eIF2Bdelta Antibody

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Overview

Name:	Anti-eIF2Bdelta Antibody See all eIF2Bdelta primary antibodies
Description:	Rabbit polyclonal antibody to eIF2Bdelta
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 164 and 457 of Human EIF2B4
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Target

Function:	Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Involvement in Disease:	Leukodystrophy with vanishing white matter: A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or *****hood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.
Sequence Similarities:	Belongs to the eIF-2B alpha/beta/delta subunits family.
Database Links:	Entrez Gene: 8890?Human Omim: 606687?Human SwissProt: Q9UI10?Human Unigene: 169474?Human
Synonyms:	EI2BD_HUMAN Antibody EIF 2B Antibody eIF 2B GDP GTP exchange factor subunit delta Antibody eIF-2B GDP-GTP exchange factor subunit delta Antibody eIF2B4 Antibody EIF2Bdelta Antibody eukaryotic translation initiation factor 2B subunit 4 Antibody Translation initiation factor eIF-2B subunit delta Antibody
Information:	Target information shown above is from the UniProt Consortium.