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Anti-EFCAB4B Antibody

品牌：Antibodies

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规格：100µl

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Anti-EFCAB4B Antibody

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Name:	Anti-EFCAB4B Antibody See all EFCAB4B primary antibodies
Description:	Rabbit polyclonal antibody to EFCAB4B
Applications:	E, WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Raised against a 14 amino acid peptide near the carboxy terminus of human EFCAB4B.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Function:	Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocations and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex (By similarity).
Sequence Similarities:	Belongs to the EFCAB4 family.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 84766?Human Entrez Gene: 381812?Mouse Omim: 614178?Human SwissProt: Q9BSW2?Human SwissProt: Q3UP38?Mouse Unigene: 504534?Human Unigene: 296093?Mouse
Synonyms:	Calcium release-activated calcium channel regulator 2A Antibody CRAC channel regulator 2A Antibody CRACR2A Antibody EF hand calcium binding domain 4B Antibody EF hand calcium binding domain containing protein 4B Antibody EF-hand calcium-binding domain-containing protein 4B Antibody EFC4B_HUMAN Antibody EFCAB 4B Antibody EFCAB4B Antibody FLJ33805 Antibody MGC4266 Antibody
Information:	Target information shown above is from the UniProt Consortium.