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Anti-CDC34 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-CDC34 Antibody

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Overview

Name:	Anti-CDC34 Antibody See all CDC34 primary antibodies
Description:	Rabbit polyclonal antibody to CDC34.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CDC34.
Protein Length:	236
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
Tissue Specificity:	Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription.
Sequence Similarities:	Belongs to the ubiquitin-conjugating enzyme family.
Post-Translational Modification:	Autoubiquitinated. Autoubiquitination is promoted by the human herpes virus 1 protein ICP0 and leads to degradation by the Ubiquitin-proteasomal pathway.
Cellular locations:	Cytoplasm. Nucleus. The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
Database Links:	Entrez Gene: 997?Human Entrez Gene: 216150?Mouse Entrez Gene: 299602?Rat Omim: 116948?Human SwissProt: P49427?Human SwissProt: Q8CFI2?Mouse Unigene: 514997?Human Unigene: 21981?Mouse Unigene: 2427?Rat
Synonyms:	Cdc 34 Antibody Cdc34 Antibody Cell division cycle 34 Antibody Cell division cycle 34 homolog Antibody Cell division cycle 34 homolog (S. cerevisiae) Antibody E2 CDC34 Antibody UB2R1_HUMAN Antibody UBC 3 Antibody UBC3 Antibody UBCH3 Antibody UBE2 R1 Antibody UBE2R1 Antibody Ubiquitin carrier protein Antibody Ubiquitin conjugating enzyme Cdc34 Antibody Ubiquitin conjugating enzyme E2 32 kDa complementing Antibody Ubiquitin protein ligase Antibody Ubiquitin protein ligase R1 Antibody Ubiquitin-conjugating enzyme E2 R1 Antibody Ubiquitin-conjugating enzyme E2-32 kDa complementing Antibody Ubiquitin-conjugating enzyme E2-CDC34 Antibody Ubiquitin-protein ligase R1 Antibody
Information:	Target information shown above is from the UniProt Consortium.