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Anti-CASP14 Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-CASP14 Antibody

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Overview

Name:	Anti-CASP14 Antibody See all CASP14 primary antibodies
Description:	Rabbit polyclonal antibody to CASP14.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:10 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human CASP14.
Protein Length:	242
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Tissue Specificity:	Expressed in keratinocytes of ***** skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form (PubMed:22825846). Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme (PubMed:12200134).
Cellular locations:	Cytoplasm. Nucleus.
Database Links:	Entrez Gene: 23581?Human Omim: 605848?Human SwissProt: P31944?Human Unigene: 466057?Human
Synonyms:	Apoptosis related cysteine protease Antibody CASP 14 Antibody CASP-14 Antibody CASP14 Antibody Caspase 14 apoptosis related cysteine protease Antibody Caspase 14 precursor Antibody Caspase-14 Antibody Caspase-14 subunit p10 Antibody Caspase14 Antibody CASPE_HUMAN Antibody MGC119078 Antibody MGC119079 Antibody MICE Antibody Mini ICE Antibody
Information:	Target information shown above is from the UniProt Consortium.