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Anti-Cannabinoid receptor 2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Cannabinoid receptor 2 Antibody

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Overview

Name:	Anti-Cannabinoid receptor 2 Antibody See all Cannabinoid receptor 2 primary antibodies
Description:	Rabbit polyclonal antibody to Cannabinoid receptor 2
Specificity:	Human
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Recombinant protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity purified
Concentration:	1.0mg / ml
Formulation:	PBS, pH 7.4 with 0.02% Sodium Azide
Storage:	This product is stable for several weeks at 4?C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20?C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Target

Function:	Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Tissue Specificity:	Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes.
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification:	Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
Cellular locations:	Cell membrane. Cell projection > Dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Database Links:	Entrez Gene: 1269?Human Omim: 605051?Human SwissProt: P34972?Human Unigene: 73037?Human
Synonyms:	Cannabinoid receptor 2 Antibody Cannabinoid receptor 2 macrophage Antibody Cannabinoid Receptor II Antibody CB 2 Antibody CB-2 Antibody CB2 Antibody CNR2 Antibody CNR2_HUMAN Antibody CNRII Antibody CX 5 Antibody CX5 Antibody hCB2 Antibody testis-dominant CNR2 isoform CB2 Antibody
Information:	Target information shown above is from the UniProt Consortium.