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Anti-SYNCRIP Antibody

品牌：Antibodies

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规格：50µl

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Anti-SYNCRIP Antibody

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Overview

Name:	Anti-SYNCRIP Antibody See all SYNCRIP primary antibodies
Description:	Rabbit polyclonal antibody to SYNCRIP.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SYNCRIP.
Protein Length:	623 (527)
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
Tissue Specificity:	Ubiquitously expressed. Detected in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood and testis.
Post-Translational Modification:	Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity).
Cellular locations:	Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity).
Database Links:	Entrez Gene: 10492?Human Entrez Gene: 56403?Mouse Entrez Gene: 363113?Rat SwissProt: O60506?Human SwissProt: Q7TMK9?Mouse SwissProt: Q7TP47?Rat Unigene: 571177?Human Unigene: 260545?Mouse Unigene: 202606?Rat
Synonyms:	cytoplasmic RNA-interacting protein Antibody dJ3J17.2 Antibody Glycine and tyrosine rich RNA binding protein Antibody Glycine- and tyrosine-rich RNA-binding protein Antibody GRY RBP Antibody GRY-RBP Antibody GRYRBP Antibody Heterogeneous nuclear ribonucleoprotein Q Antibody hnRNP Q Antibody HNRPQ Antibody HNRPQ1 Antibody HNRPQ_HUMAN Antibody NS1 associated protein 1 Antibody NS1-associated protein 1 Antibody NSAP1 Antibody pp68 Antibody RP1 3J17.2 Antibody Synaptotagmin binding cytoplasmic RNA interacting protein Antibody Synaptotagmin-binding Antibody Syncrip Antibody
Information:	Target information shown above is from the UniProt Consortium.