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Anti-AIFM1 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-AIFM1 Antibody

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Overview

Name:	Anti-AIFM1 Antibody See all AIFM1 primary antibodies
Description:	Goat polyclonal antibody to AIFM1.
Applications:	ELISA, WB
Reactivity:	Human, Mouse, Rat, Porcine
Immunogen:	Synthetic peptide corresponding to Human AIFM1 (C terminal).
Sequence:	C-NEVAKLFNIHED
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis,and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner (By similarity).
Sequence Similarities:	Belongs to the FAD-dependent oxidoreductase family.
Post-Translational Modification:	Under normal conditions, a 54-residue N-terminal segment is first proteolytically removed during or just after translocations into the mitochondrial intermembrane space (IMS) by the mitochondrial processing peptidase (MPP) to form the inner-membrane-anchored mature form (AIFmit). During apoptosis, it is further proteolytically processed at amino-acid position 101 leading to the generation of the mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis in a caspase-independent manner (By similarity).
Cellular locations:	Mitochondrion intermembrane space. Mitochondrion inner membrane. Cytoplasm. Cytoplasm > Perinuclear region. Nucleus. Proteolytic cleavage during or just after translocations into the mitochondrial intermembrane space (IMS) results in the formation of an inner-membrane-anchored mature form (AIFmit). During apoptosis, further proteolytic processing leads to a mature form, which is confined to the mitochondrial IMS in a soluble form (AIFsol). AIFsol is released to the cytoplasm in response to specific death signals, and translocated to the nucleus, where it induces nuclear apoptosis. Colocalizes with EIF3G in the nucleus and perinuclear region (By similarity).
Database Links:	Entrez Gene: 51060 Human Entrez Gene: 9131 Human Entrez Gene: 26926 Mouse Entrez Gene: 100524062 Pig Entrez Gene: 83533 Rat Omim: 300169 Human SwissProt: O95831 Human SwissProt: Q9Z0X1 Mouse SwissProt: Q9JM53 Rat Unigene: 424932 Human Unigene: 476033 Human Unigene: 240434 Mouse Unigene: 203165 Rat
Synonyms:	AIF Antibody AIFM1 Antibody AIFM1_HUMAN Antibody AIFsh2 Antibody Apoptosis inducing factor Antibody Apoptosis inducing factor 1, mitochondrial Antibody Apoptosis inducing factor, mitochondrion associated, 1 Antibody Apoptosis-inducing factor Antibody Apoptosis-inducing factor 1 Antibody Apoptosis-inducing factor 1, mitochondrial Antibody Apoptosis-inducing factor, mitochondrion-associated, 1 Antibody CMTX4 Antibody COWCK Antibody COXPD6 Antibody Harlequin Antibody Hq Antibody mAIF Antibody MGC111425 Antibody MGC5706 Antibody mitochondrial Antibody Neuropathy, axonal motor-sensory, with deafness and mental retardation Antibody neuropathy, axonal, motor-sensory with deafness and mental retardation (Cowchock syndrome) Antibody PDCD 8 Antibody PDCD8 Antibody Programmed cell death 8 Antibody Programmed cell death 8 (apoptosis inducing factor) Antibody Programmed cell death 8 isoform 1 Antibody Programmed cell death 8 isoform 2 Antibody Programmed cell death 8 isoform 3 Antibody Programmed cell death protein 8 Antibody Programmed cell death protein 8 mitochondrial Antibody Programmed cell death protein 8 mitochondrial precursor Antibody Striatal apoptosis inducing factor Antibody
Information:	Target information shown above is from the UniProt Consortium.