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Anti-LIG3 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-LIG3 Antibody

商品详情参考文献相关资料

Name:	Anti-LIG3 Antibody See all LIG3 primary antibodies
Description:	Rabbit polyclonal antibody to LIG3.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human LIG3.
Protein Length:	1009
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627).
Tissue Specificity:	Testis, thymus, prostate and heart.
Sequence Similarities:	Belongs to the ATP-dependent DNA ligase family.
Cellular locations:	Mitochondrion. Contains an N-terminal mitochondrial transit peptide.