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Anti-SIAH1 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-SIAH1 Antibody

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Overview

Name:	Anti-SIAH1 Antibody See all SIAH1 primary antibodies
Description:	Goat polyclonal antibody to SIAH1.
Applications:	ELISA, WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide corresponding to Human SIAH1 (N terminal).
Sequence:	SRQTATALPTGTSKC
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (ELL2, MYB, POU2AF1, PML and RBBP8), a cell surface receptor (DCC), cytoplasmic signal transduction molecules (KLF10/TIEG1 and NUMB), an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP), a structural protein (CTNNB1) and SNCAIP. Confers constitutive instability to HIPK2 through proteasomal degradation. It is thereby involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription, spermatogenesis and TNF-alpha signaling. Has some overlapping function with SIAH2. Induces apoptosis in cooperation with PEG3 (By similarity). Upon nitric oxid (NO) generation that follows apoptotic stimulation, interacts with S-nitrosylated GAPDH, mediating the translocations of GAPDH to the nucleus. GAPDH acts as a stabilizer of SIAH1, facilitating the degradation of nuclear proteins.
Sequence Similarities:	Belongs to the SINA (Seven in absentia) family.
Post-Translational Modification:	Phosphorylated on Ser-19 by ATM and ATR. This phosphorylation disrupts SIAH1 interaction with HIPK2, and subsequent proteasomal degradation of HIPK2 (By similarity).
Cellular locations:	Cytoplasm. Nucleus. Predominantly cytoplasmic. Partially nuclear.
Database Links:	Entrez Gene: 6477 Human Entrez Gene: 20437 Mouse Entrez Gene: 140941 Rat Omim: 602212 Human SwissProt: Q8IUQ4 Human SwissProt: P61092 Mouse SwissProt: Q920M9 Rat Unigene: 706828 Human Unigene: 713615 Human Unigene: 73937 Rat
Synonyms:	E3 ubiquitin-protein ligase SIAH1 Antibody FLJ08065 Antibody hSIAH1 Antibody HUMSIAH Antibody Seven in absentia homolog 1 Antibody Seven in absentia homolog 1 (Drosophila) Antibody Siah 1 Antibody Siah 1a Antibody Siah E3 ubiquitin protein ligase 1 Antibody Siah-1 Antibody Siah-1a Antibody SIAH1 Antibody SIAH1A Antibody SIAH1_HUMAN Antibody Ubiquitin ligase SIAH1 Antibody
Information:	Target information shown above is from the UniProt Consortium.