产品介绍 品名 Monoclonal Antibody to Human Clusterin 货号 A241 规格 100 µL 同种型 IgG1K 蛋白质浓度 > 1.0 mg/mL 纯度 ≥ 95% by SDS PAGE 缓冲液 Borate Buffered Saline (pH 8.4 ± 0.2) 物种交叉反应 None tested. 储存 ≤ 30 Days 2-8˚C > 30 Days ≤ –20˚C 产品背景 Clusterin, also called complement lysis inhibitor, SP-40, 40, Apolipoprotein J (Apo J), is a 449 amino acid protein with a molecular weight of 75-80 kD. Clusterin is a heterodimer consisting of alpha and beta chains of approximately equal size (35-40 kD); the chains being linked by a unique five-disulfide bond motif. Serum concentration of clusterin is 50-100 µg/mL and is present in most organs, with the highest level of mRNA expression in brain, adrenal medulla, ovary, testis and liver. Within the complement system, clusterin modulates the function of the Terminal Complement cascade to prevent lysis by the Membrane Attack Complex (C5b-9). Clusterin is found in non-lytic C5b-9 complexes, which also contain Vitronectin. Clusterin binds to C5b-7, C5b-8 or C5b-9 during assembly of the amphiphillic complex. 特异性 The specificity of the monoclonal antibody was established via ELISA. This antibody was shown to bind purified clusterin protein. The antibody reacts with native, heterodimeric clusterin, but does not react with either of the separated clusterin alpha or beta subunits. 产品应用 使用说明 For Research Use Only.Not for use in Diagnostic Procedures
产品介绍
Monoclonal Antibody to Human Clusterin
A241
100 µL
IgG1K
> 1.0 mg/mL
≥ 95% by SDS PAGE
Borate Buffered Saline (pH 8.4 ± 0.2)
None tested.
≤ 30 Days 2-8˚C
> 30 Days ≤ –20˚C
Clusterin, also called complement lysis inhibitor, SP-40, 40, Apolipoprotein J (Apo J), is a 449 amino acid protein with a molecular weight of 75-80 kD. Clusterin is a heterodimer consisting of alpha and beta chains of approximately equal size (35-40 kD); the chains being linked by a unique five-disulfide bond motif.
Serum concentration of clusterin is 50-100 µg/mL and is present in most organs, with the highest level of mRNA expression in brain, adrenal medulla, ovary, testis and liver.
Within the complement system, clusterin modulates the function of the Terminal Complement cascade to prevent lysis by the Membrane Attack Complex (C5b-9). Clusterin is found in non-lytic C5b-9 complexes, which also contain Vitronectin. Clusterin binds to C5b-7, C5b-8 or C5b-9 during assembly of the amphiphillic complex.
The specificity of the monoclonal antibody was established via ELISA. This antibody was shown to bind purified clusterin protein. The antibody reacts with native, heterodimeric clusterin, but does not react with either of the separated clusterin alpha or beta subunits.
For Research Use Only.Not for use in Diagnostic Procedures
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